| Game Show | Weakest Link |
| Pierce Brosnan | ... | Anne's father |
| Madeleine Martin | ... | young Anne |
| Rachel Dratch | ... | Anne Robinson |
| Jimmy Fallon | ... | R.J. |
| Will Ferrell | ... | Dennis |
| Ana Gasteyer | ... | Yvette |
| Darrell Hammond | ... | announcer Voice |
| Chris Kattan | ... | Dale |
| Jerry Minor | ... | Daschle |
| Tracy Morgan | ... | Carl |
| Maya Rudolph | ... | Tamara |
| Horatio Sanz | ... | Dan |
| Sean Sanders | ... | son |