| Game Show | What's Wrong With Tanya?! “Lifetime Game Show” |
| Anna Faris | ... | Mary Jo Beth Jojo |
| Abby Elliott | ... | Tanya |
| Bill Hader | ... | Vince Blake#5 |
| Andy Samberg | ... | Boy Tanya |
| Kristen Wiig | ... | JoBeth Anderson |
| Kristen Wiig | ... | announcer Voice |
| Vanessa Bayer | ... | Mary Jo Williams |