| Cold Opening | Second Presidential Debate |
| Rachel Dratch | ... | Carla Tamborello |
| Will Forte | ... | George W. Bush#5 Live |
| Seth Meyers | ... | John Kerry#10 |
| Chris Parnell | ... | Charles Gibson |
| Amy Poehler | ... | Cheryl Spander |
| Maya Rudolph | ... | Nikki Washington |
| Rob Riggle | ... | Anthony Baldi |
| John Lutz | ... | audience member |
| Paula Pell | ... | Linda Grabel |
| Sarah-Ann Rodgers | ... | audience member |