| Sketch | Mysteries In Medicine |
| Steve Martin | ... | Dr. Paul Cone |
| Dan Aykroyd | ... | announcer Voice |
| John Belushi | ... | Dr. Mike Blog |
| Jane Curtin | ... | Violet Elmweather |
| Laraine Newman | ... | Midge |
| Michael O'Donoghue | ... | Hector |
| Don Pardo | ... | announcer Voice |
| Alan Zweibel | ... | Ernie |