| Sketch | Craig Sundberg, Idiot Savant |
| Oprah Winfrey | ... | scientist |
| Nora Dunn | ... | mother |
| Anthony Michael Hall | ... | Craig Sundberg |
| Jon Lovitz | ... | Mr. Undersecretary |
| Don Pardo | ... | announcer Voice |
| Randy Quaid | ... | guard |
| Terry Sweeney | ... | scientist |
| Akira Yoshimura | ... | Professor Chin |