| Show | The Dan Quayle Show |
| Mary Tyler Moore | ... | Marilyn Quayle |
| Jeff Renaudo | ... | Tucker Quayle |
| Dana Carvey | ... | Dan Quayle |
| Nora Dunn | ... | Rose Marie /Sally Rogers |
| Jon Lovitz | ... | Morey Amsterdam /Buddy Sorrell |
| Kevin Nealon | ... | announcer Voice |
| John Bowman | ... | Secret Service agent |
| Tom Davis | ... | Secret Service agent |