| Cartoon | George Clooney The Sexiest Car Alive |
| Stephen Colbert | ... | George Clooney Voice |
| Stephen Colbert | ... | Steve Thomas Voice |
| Ana Gasteyer | ... | Diane Sawyer Voice |
| Darrell Hammond | ... | Dan Rather Voice |
| Darrell Hammond | ... | Eddie Murphy Voice |
| Darrell Hammond | ... | Gary Burghoff Voice |
| Darrell Hammond | ... | photographer Voice |
| Darrell Hammond | ... | reporter Voice |
| Cheri Oteri | ... | Barbara Walters Voice |
| Robert Smigel | ... | Fran Drescher Voice |
| Robert Smigel | ... | Manny Voice |
| Robert Smigel | ... | Marv Albert Voice |
| Robert Smigel | ... | narrator Voice |
| Robert Smigel | ... | reporter Voice |