| Cold Opening | Press Conference |
| Dean Edwards | ... | reporter |
| Ana Gasteyer | ... | Helen Thomas |
| Darrell Hammond | ... | John Ashcroft Live |
| Chris Kattan | ... | Dr. Anthony Fauci |
| Seth Meyers | ... | Brian Williams |
| Dean Obeidallah | ... | aide |
| Jeff Richards | ... | reporter |
| Maya Rudolph | ... | reporter |