| Cold Opening | Second Presidential Debate |
| Bill Murray | ||
| Chris Parnell | ... | Tom Brokaw#21 Live |
| Fred Armisen | ... | Barack Obama#7 |
| Bill Hader | ... | Kevin Quigley |
| Darrell Hammond | ... | John McCain#5 |
| Bobby Moynihan | ... | Anthony Cipelli |
| Andy Samberg | ... | David Kip |
| Jason Sudeikis | ... | Mark Ladue |
| Kenan Thompson | ... | Dalton Cheeks |
| Kristen Wiig | ... | Susan Calkins |
| Casey Wilson | ... | Elizabeth Wheeler |
| Steve Higgins | ... | announcer Voice |
| Bill Corsair | ... | voter |