| Cold Opening | Second Presidential Debate |
| Tom Hanks | ... | Kerry Lapkis |
| Fred Armisen | ... | Jeremy Blaustein |
| Bill Hader | ... | Eugene Picanzi |
| Taran Killam | ... | Tagg Romney |
| Bobby Moynihan | ... | Dominic Fonte |
| Jay Pharoah | ... | Barack Obama |
| Jason Sudeikis | ... | Mitt Romney |
| Aidy Bryant | ... | Candy Crowley Live |
| Kate McKinnon | ... | Teresa Cucinelly |
| Cecily Strong | ... | Lisa Goldstein |