| Cold Opening | Mayweather-Pacquiao Fight |
| Aidy Bryant | ... | Manny Pacquiao Live |
| Taran Killam | ... | Michael Buffer |
| Kate McKinnon | ... | Justin Bieber#7 |
| Jay Pharoah | ... | Floyd Mayweather |
| Kenan Thompson | ... | Kenny Bayless |
| Steve Higgins | ... | announcer Voice |
| Randy Clark | ... | audience member |