| Cold Opening | Democratic Presidential Debate |
| Alec Baldwin | ... | Jim Webb |
| Larry David | ... | Bernie Sanders Live |
| Taran Killam | ... | Martin O'Malley |
| Kate McKinnon | ... | Hillary Clinton Live |
| Kyle Mooney | ... | Lincoln Chafee |
| Jon Rudnitsky | ... | Anderson Cooper |
| Takako Haywood | ... | audience member |