| Cold Opening | Democratic Presidential Debate |
| Julia Louis-Dreyfus | ... | Elaine Benes Live |
| Larry David | ... | Bernie Sanders Live |
| Vanessa Bayer | ... | Rachel Green |
| Beck Bennett | ... | Wolf Blitzer |
| Kate McKinnon | ... | Hillary Clinton Live |
| Kenan Thompson | ... | Errol Louis |
| Danny Peter Smith | ... | audience member |