| Cold Opening | Pence Gets The Vaccine |
| Maya Rudolph | ... | Kamala Harris Live |
| Beck Bennett | ... | Mike Pence Live |
| Mikey Day | ... | doctor Live |
| Steve Higgins | ... | announcer Voice |
| Lauren Holt | ... | Karen Pence Live |
| Kate McKinnon | ... | Rudy Giuliani |
| Alex Moffat | ... | Joe Biden Live |
| Kenan Thompson | ... | Ben Carson |