May 8, 2021#1
| Cold Opening | Mother's Day |
| Miley Cyrus | Live | |
| Sarah Bennett | Live | |
| Georganne Bryant | Live | |
| Laura Campbell | Live | |
| Tish Cyrus | Live | |
| Amy Davidson | Live | |
| Sylvia Day | Live | |
| Ego Nwodim's mother | Live | |
| Ellen Gunn | Live | |
| Lyn Holt | Live | |
| Erny Huelke | Live | |
| Mary Johnson | Live | |
| Kerry Kelly | Live | |
| Linda Mooney | Live | |
| Margaret Redd | Live | |
| Penny Strong | Live | |
| Elizabeth Thompson | Live | |
| Lupe Villaseñor | Live | |
| Meng Yang | Live | |
| Beck Bennett | Live | |
| Aidy Bryant | Live | |
| Pete Davidson | Live | |
| Mikey Day | Live | |
| Chloe Fineman | Live | |
| Heidi Gardner | Live | |
| Lauren Holt | Live | |
| Punkie Johnson | Live | |
| Colin Jost | Live | |
| Kate McKinnon | Live | |
| Kyle Mooney | Live | |
| Ego Nwodim | Live | |
| Chris Redd | Live | |
| Cecily Strong | Live | |
| Kenan Thompson | Live | |
| Melissa Villaseñor | Live | |
| Bowen Yang | Live |