| Cold Opening | Vice Presidential Debate |
| Alec Baldwin | ... | Donald Trump#2 Live |
| Beck Bennett | ... | Mike Pence#1 |
| Kate McKinnon | ... | Hillary Clinton#17 |
| Cecily Strong | ... | Brooke Baldwin#2 |
| Mikey Day | ... | Tim Kaine#1 |
| Melissa Villaseñor | ... | Elaine Quijano |
| Steve Higgins | ... | announcer Voice |
| Bryan Amato | ... | supporter |
| Alex Hollock | ... | supporter |