| Cold Opening | Democratic Debate |
| Larry David | ... | Bernie Sanders#13 Live |
| Rachel Dratch | ... | Amy Klobuchar#4 Live |
| Jason Sudeikis | ... | Joe Biden#26 Live |
| Pete Davidson | ... | Tom Steyer Live |
| Mikey Day | ... | George Stephanopoulos#1 |
| Colin Jost | ... | Pete Buttigieg#5 Live |
| Kate McKinnon | ... | Elizabeth Warren#10 Live |
| Alex Moffat | ... | David Muir |
| Kenan Thompson | ... | audience member |
| Ego Nwodim | ... | Linsey Davis |
| Bowen Yang | ... | Andrew Yang#4 Live |
| Steve Higgins | ... | announcer Voice |