| Cold Opening | A Holiday Message from former Vice President Joe Biden |
| Jim Carrey | ... | Joe Biden#5 Live |
| Maya Rudolph | ... | Kamala Harris#7 Live |
| Beck Bennett | ... | Mitch McConnell#7 |
| Mikey Day | ... | Nate Silver |
| Kate McKinnon | ... | Hillary Clinton#28 |
| Chris Redd | ... | Lil Wayne#2 |
| Kenan Thompson | ... | Ice Cube#3 |
| Steve Higgins | ... | announcer Voice |