| Cold Opening | A Holiday Message From Dr. Anthony Fauci |
| Aidy Bryant | ... | Ted Cruz#7 Live |
| Pete Davidson | ... | Andrew Cuomo#5 Live |
| Mikey Day | ... | CDC player Live |
| Chloe Fineman | ... | Lauren Boebert#1 Live |
| Heidi Gardner | ... | CDC player Live |
| Kate McKinnon | ... | Dr. Anthony Fauci#5 Live |
| Kyle Mooney | ... | CDC player Live |
| Ego Nwodim | ... | CDC player#2 Live |
| Cecily Strong | ... | Marjorie Taylor Greene#5 Live |
| Melissa Villaseñor | ... | CDC player Live |
| Bowen Yang | ... | CDC player#2 Live |
| Andrew Dismukes | ... | Chris Cuomo Live |
| Steve Higgins | ... | announcer Voice |